Non-Immunosuppressive Cyclosporine Analogue Molecules, NICAM

[Mike Bartolatz]

http://micro.newswire.ca/release.cgi?rk ... rt=0&htm=0

non-immunosuppressive cyclosporine analogue molecules (NICAMs)


" EDMONTON, Oct. 29 /CNW/ - Isotechnika Pharma Inc. (TSX: ISA) today
announced that it has developed a portfolio of non-immunosuppressive
cyclosporine analogue molecules (NICAMs) with potent cyclophilin inhibition.
Cyclophilin inhibition has garnered considerable attention as a novel therapy
in the treatment of a wide range of diseases including hepatitis C, stroke,
and chronic neurological disorders such as Parkinson's, Lou Gehrig's, and
Alzheimer's. Cyclosporine A is a well established cyclophilin inhibitor,
however, its additional strong binding to calcineurin results in powerful
immunosuppression and limits its therapeutic potential to transplantation and
various autoimmune disorders. NICAMs do not bind to calcineurin yet retain
the ability to inhibit cyclophilin"