IL23R, ERAP1. IL23R, ANTXR2, IL1R2, 4 major disorders
Posted: Sun Nov 30, 2008 1:15 pm
The ARTS 1 gene is also known as the ERAP 1 gene: http://www.ncbi.nlm.nih.gov/sites/entre ... uids=51752
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http://parsplanitisforum.yuku.com/topic/28
here are some newly discovered genetic links to Ankylosing spondlyitis and other autoimmune disease processes
recently the ANTXR2 and IL1R2 genes were discovered and the association with IL23R and ERAP1 (formerly ARTS!) genes were confirmed so in addition to HLA B27 the following genes are linked in anglo american and european persons:
HLA B27
ANTXR2
IL1R2
IL23R
ERAP1 (formerly ARTS1)
http://www.medscape.com/viewarticle/564590
"The diseases linked to these genes are ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis, and breast cancer.
The investigators suggest that IL23R, in particular, may be a common susceptibility factor for the major "seronegative" diseases. Earlier research has shown an association between IL23R and both inflammatory bowel disease (Crohn's disease) and psoriasis. "
http://www.medscape.com/viewarticle/566849?src=mp
research article
Ankylosing Spondylitis, Crohn's disease, Systemic Lupus Erythematosis, Multiple Sclerosis
http://www.medscape.com/viewarticle/564590
expanded search on IL23 in Uvieitis shows increase in this cytokine in Behcet's patients,VKH patients etc
http://www.google.com/search?hl=en&q=IL ... h&aq=f&oq=
patent for anti IL23 in uveitis:
http://www.freshpatents.com/Use-of-il-2 ... 199460.php
research (with mice) and patent information
http://www.wipo.int/pctdb/en/wo.jsp?IA= ... SPLAY=DESC
simvastatin used to treat cholesterol levels inhibits IL17
http://www.jimmunol.org/cgi/content/abs ... 80/10/6988
---------------------
http://parsplanitisforum.yuku.com/topic/28
here are some newly discovered genetic links to Ankylosing spondlyitis and other autoimmune disease processes
recently the ANTXR2 and IL1R2 genes were discovered and the association with IL23R and ERAP1 (formerly ARTS!) genes were confirmed so in addition to HLA B27 the following genes are linked in anglo american and european persons:
HLA B27
ANTXR2
IL1R2
IL23R
ERAP1 (formerly ARTS1)
http://www.medscape.com/viewarticle/564590
"The diseases linked to these genes are ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis, and breast cancer.
The investigators suggest that IL23R, in particular, may be a common susceptibility factor for the major "seronegative" diseases. Earlier research has shown an association between IL23R and both inflammatory bowel disease (Crohn's disease) and psoriasis. "
http://www.medscape.com/viewarticle/566849?src=mp
research article
Ankylosing Spondylitis, Crohn's disease, Systemic Lupus Erythematosis, Multiple Sclerosis
http://www.medscape.com/viewarticle/564590
expanded search on IL23 in Uvieitis shows increase in this cytokine in Behcet's patients,VKH patients etc
http://www.google.com/search?hl=en&q=IL ... h&aq=f&oq=
patent for anti IL23 in uveitis:
http://www.freshpatents.com/Use-of-il-2 ... 199460.php
research (with mice) and patent information
http://www.wipo.int/pctdb/en/wo.jsp?IA= ... SPLAY=DESC
simvastatin used to treat cholesterol levels inhibits IL17
http://www.jimmunol.org/cgi/content/abs ... 80/10/6988