IL23R,ARTS1 genes and autoimmune disease
Posted: Sun Nov 30, 2008 9:26 am
the IL23R and ARTS1 genes have been linked to 4 major disorders, Ankylosing spondylitis, Systemic Lupus Erythematosis, Crohn's disease and multiple sclerosis;
the IL23R gene regulates both pro inflammatory cytokines IL23 and IL17 found in the ocular fluid in some uveitis patients but especially in Behcet's disease.
below are links to information on this subject:
http://www.medscape.com/viewarticle/566849?src=mp
research article
Ankylosing Spondylitis, Crohn's disease, Systemic Lupus Erythematosis, Multiple Sclerosis
http://www.medscape.com/viewarticle/564590
expaned search on IL23 in Uvieitis shows increase in this cytokine in Behcet's patients,VKH patients etc
http://www.google.com/search?hl=en&q=IL ... h&aq=f&oq=
patent for anti IL23 in uveitis:
http://www.freshpatents.com/Use-of-il-2 ... 199460.php
research (with mice) and patent information
http://www.wipo.int/pctdb/en/wo.jsp?IA= ... SPLAY=DESC
simvastatin used to treat cholesterol levels inhibits IL17
http://www.jimmunol.org/cgi/content/abs ... 80/10/6988
the IL23R gene regulates both pro inflammatory cytokines IL23 and IL17 found in the ocular fluid in some uveitis patients but especially in Behcet's disease.
below are links to information on this subject:
http://www.medscape.com/viewarticle/566849?src=mp
research article
Ankylosing Spondylitis, Crohn's disease, Systemic Lupus Erythematosis, Multiple Sclerosis
http://www.medscape.com/viewarticle/564590
expaned search on IL23 in Uvieitis shows increase in this cytokine in Behcet's patients,VKH patients etc
http://www.google.com/search?hl=en&q=IL ... h&aq=f&oq=
patent for anti IL23 in uveitis:
http://www.freshpatents.com/Use-of-il-2 ... 199460.php
research (with mice) and patent information
http://www.wipo.int/pctdb/en/wo.jsp?IA= ... SPLAY=DESC
simvastatin used to treat cholesterol levels inhibits IL17
http://www.jimmunol.org/cgi/content/abs ... 80/10/6988