NSAID THERAPY in recurrent HLA B27 associated uveitis
Posted: Thu Dec 13, 2007 7:59 pm
The following is an excerpt from an article written by C Stephen Foster MD following the ARVO meeting in 2005. I have borrowed it and placed it here because the question often comes up as to how effective NSAID therapy is.
msb
____http://www.medscape.com/viewarticle/505926__________________________________________________________________
The efficacy of chronic oral nonsteroidal anti-inflammatory drug (NSAID) therapy for prevention of uveitis relapse in patients with a history of recurrent HLA-B27-associated uveitis was studied by Teasley and colleagues[16] at the Ocular Immunology and Uveitis Foundation in Boston. Forty-three patients (86 eyes) were studied, and the pre-NSAID and post-NSAID attack rates were compared. The average pre-NSAID attack rate was 1 episode every 12.8 months; the post-NSAID rate was 1 attack every 38.3 months, off all corticosteroid therapy. Five patients experienced gastrointestinal discomfort which was alleviated by a change in the NSAID being employed. The authors concluded that there was a 66.8% reduction in recurrences of uveitis in this population of patients with recurrent HLA-B27-associated uveitis through the chronic use of oral NSAIDs, with complete freedom from steroid use. They are now attempting to mount a double-masked, randomized, placebo-controlled clinical trial on this matter.
msb
____http://www.medscape.com/viewarticle/505926__________________________________________________________________
The efficacy of chronic oral nonsteroidal anti-inflammatory drug (NSAID) therapy for prevention of uveitis relapse in patients with a history of recurrent HLA-B27-associated uveitis was studied by Teasley and colleagues[16] at the Ocular Immunology and Uveitis Foundation in Boston. Forty-three patients (86 eyes) were studied, and the pre-NSAID and post-NSAID attack rates were compared. The average pre-NSAID attack rate was 1 episode every 12.8 months; the post-NSAID rate was 1 attack every 38.3 months, off all corticosteroid therapy. Five patients experienced gastrointestinal discomfort which was alleviated by a change in the NSAID being employed. The authors concluded that there was a 66.8% reduction in recurrences of uveitis in this population of patients with recurrent HLA-B27-associated uveitis through the chronic use of oral NSAIDs, with complete freedom from steroid use. They are now attempting to mount a double-masked, randomized, placebo-controlled clinical trial on this matter.