http://www.medicinenet.com/script/main/ ... ekey=16694
the IL23 gene also presents with Ankylosing spondyitis,
this article talks about women who have the HLA B27 gene and who get Uveitis and Ankylosing Spondylitis at a much higher frequency than the general population.
at up to 50%
mike
Ankylosing Spondylitis, uveitis and pregnancy
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Ankylosing Spondylitis, uveitis and pregnancy
Mike Bartolatz
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Moderator
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- Posts: 6595
- Joined: Fri Feb 06, 2004 9:58 pm
post partum uveitis
Postpartum uveitis.Hyman BN.
A review of the literature supports the concept that serum levels of corticosteroids are elevated during pregnancy. Even a concurrent increase in cortisol-binding globulin (CBG) does not entirely neutralize the increased levels of cortisol. Thus, body tissues are exposed to more free cortisol than in the nonpregnant state. After delivery there is a rapid reduction of serum corticosteroids to the nonpregnant level. A granulomatous disease such as sarcoidosis may be suppressed by the high serum cortisol level. In the puerperium with a reduction of the serum cortisol, exacerbation of such a disease is likely. The case presented demonstrates this phenomenon.
PMID: 937950 [PubMed - indexed for MEDLINE]
A review of the literature supports the concept that serum levels of corticosteroids are elevated during pregnancy. Even a concurrent increase in cortisol-binding globulin (CBG) does not entirely neutralize the increased levels of cortisol. Thus, body tissues are exposed to more free cortisol than in the nonpregnant state. After delivery there is a rapid reduction of serum corticosteroids to the nonpregnant level. A granulomatous disease such as sarcoidosis may be suppressed by the high serum cortisol level. In the puerperium with a reduction of the serum cortisol, exacerbation of such a disease is likely. The case presented demonstrates this phenomenon.
PMID: 937950 [PubMed - indexed for MEDLINE]
Mike Bartolatz
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