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H Pylori as a trigger in Acute Anterior Uveitis

Posted: Sun Feb 04, 2007 11:33 pm
by Mike Bartolatz
1: Infection. 2005 Apr;33(2):82-5. Links
Comment in:
Infection. 2005 Apr;33(2):49.
Helicobacter pylori infection in anterior uveitis.Otasevic L, Walduck A, Meyer TF, Aebischer T, Hartmann C, Orlic N, Pleyer U.
Dept. of Ophthalmology, Charite, Humboldt University, Berlin, Germany.

BACKGROUND: Despite intensive research, the etiology of acute anterior uveitis (AAU) remains poorly defined. Infection with gram-negative bacteria such as Yersinia, Salmonella, Shigella, and Chlamydia have already been suggested as a possible trigger event for AAU. Helicobacter pylori is also a gram-negative bacterium, shares the lipopolysaccharides, but did not attract the attention of many ophthalmologists until recently. Having in mind the relatively high incidence of H. pylori infection in the population, we propose that H. pylori may also be a trigger factor for AAU. PATIENTS AND METHODS: The presence of anti-H. pylori antibodies in matching serum and aqueous humor samples of 15 idiopathic AAU patients was determined using a commercial Western blot assay. Control serum and aqueous humor were obtained from five patients undergoing cataract surgery. RESULTS: Six out of 15 AAU patients (40%) were serum-positive for H. pylori, and half of these (n = 3) also had anti-H. pylori antibodies in the aqueous humor. All five aqueous humor and sera controls tested negative for H. pylori infection. CONCLUSION: These are the first results demonstrating anti-H. pylori antibodies in the aqueous humor of AAU patients. Further studies are needed to demonstrate whether this antibody is indeed locally produced. Our data may provide first evidence for a causative link between H. pylori infection and AAU.

PMID: 15827876 [PubMed - indexed for MEDLINE]
Related LinksHelicobacter pylori: an underestimated factor in acute anterior uveitis and spondyloarthropathies? [Ophthalmologica. 2007] PMID: 17183194 Increased levels of Helicobacter pylori IgG antibodies in aqueous humor of patients with primary open-angle and exfoliation glaucoma. [Graefes Arch Clin Exp Ophthalmol. 2003] PMID: 14576945 Prevalence and levels of serum antibodies to gram negative microorganisms in Turkish patients with HLA-B27 positive acute anterior uveitis and controls. [Ocul Immunol Inflamm. 2006] PMID: 17056463 IgA antibodies against Klebsiella and other Gram-negative bacteria in ankylosing spondylitis and acute anterior uveitis. [Clin Rheumatol. 1996] PMID: 8835503 Infectious background of patients with a history of acute anterior uveitis. [Ann Rheum Dis. 2002] PMID: 12379526 See all Related Articles...

Posted: Sat Jul 28, 2007 10:19 am
by Mike Bartolatz