HLA B27

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Mike Bartolatz
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Post by Mike Bartolatz » Sat Feb 17, 2007 3:50 pm

http://iritis.org/forum/viewtopic.php?t=1209

this would be the best information that I know of regarding who will get uveitis with the HLA B27 gene,


mike
Mike Bartolatz
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Mike Bartolatz
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Post by Mike Bartolatz » Tue Nov 20, 2007 10:36 am

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http://www.iritis.org/forum/viewtopic.php?t=156

http://www.iritis.org/forum/viewtopic.php?t=1207

http://www.iritis.org/forum/viewtopic.php?t=1209

http://www.iritis.org/forum/viewtopic.php?t=2456

http://www.iritis.org/forum/viewtopic.php?t=2230 CARD 15 GENE, Sarcoidosis, Blau Syndrome and Crohn's disease


http://www.emedicine.com/med/topic3098.htm Enteropathic Arthropathies

http://www.iritis.org/forum/viewtopic.php?t=2131 Psoriasis and Uveitis

Sero negative spondyloarthropathies
http://www.google.com/search?hl=en&q=Se ... gle+Search
these are rheumatoid Factor (RF negative) forms of arthritis most often but not always related to the HLA B27 family of genes (yes there are a bunch of them)
Mike Bartolatz
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Mike Bartolatz
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HLA B27's positive role in preventing Hepatitis C disease

Post by Mike Bartolatz » Tue Mar 25, 2008 3:06 pm

Eur J Gastroenterol Hepatol. 2007 Jun ;19 (6):493-498 17489060 (P,S,E,B,D) Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02.

[My paper] Claire Smyth, Susan McKiernan, Richard Hagan, Ruth Pilkington, Myra Oʼregan, Emer Lawlor, Dermot Kelleher
aDepartment of Clinical Medicine bIrish Blood Transfusion Service, St Jamesʼ Hospital, Dublin cDepartment of Statistics, Trinity College Dublin, Dublin, Ireland.
BACKGROUND: Hepatitis C virus infection is a major cause of nonA, nonB hepatitis worldwide. A high prevalence of immunological abnormalities has been shown to occur in patients with chronic hepatitis C virus infection. AIM: The aim of this study was to assess the development of sicca syndrome in a cohort of patients infected with a single strain of hepatitis C virus, namely genotype 1b, and correlate this with viral persistence and human leukocyte antigen type of the patients. METHODS: Ninety-five patients infected with the single strain hepatitis C virus were used in this study, 32 of whom were polymerase chain reaction-negative and 63 polymerase chain reaction-positive. Patient details were reviewed for symptoms consistent with sicca syndrome. Human leukocyte antigen class I (A, B and C) and class II (DRB and DQB1) typing was performed on all patients. Auto-antibodies were also measured. RESULTS: DQB1*02 was highly significantly associated with viral persistence (P<0.0001). Nineteen of 21 patients with sicca syndrome were hepatitis C virus-polymerase chain reaction-positive demonstrating a strong association with viral persistence and the development of the syndrome. Human leukocyte antigen DQB1*02 was significantly associated with the development of sicca syndrome, P=0.02. CONCLUSION: The development of autoimmune disease in patients with chronic hepatitis C virus infection depends on the interaction of multiple factors. This study suggests that important factors in this process are viral persistence and human leukocyte antigen type of the patients. Hepatology. 2006 Feb 22;43 (3):563-572 16496339 (P,S,E,B,D) Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.

[My paper] Christoph Neumann-Haefelin, Susan McKiernan, Scott Ward, Sergei Viazov, Hans Christian Spangenberg, Thomas Killinger, Thomas F Baumert, Natalja Nazarova, Isabelle Sheridan, Oliver Pybus, Fritz von Weizsäcker, Michael Roggendorf, Dermot Kelleher, Paul Klenerman, Hubert E Blum, Robert Thimme
Department of Medicine II, University of Freiburg, Germany.
Virus-specific CD8+ T cell responses play an important role in the natural course of infection; however, the impact of certain CD8+ T cell responses in determining clinical outcome has not been fully defined. A well-defined cohort of women inoculated with HCV from a single source showed that HLA-B27 has a strong association with spontaneous clearance. The immunological basis for this association is unknown. However, the finding is especially significant because HLA-B27 has also been shown to have a protective role in HIV infection. We report the identification of an HLA-B27 restricted hepatitis C virus (HCV)-specific CD8+ T cell epitope that is recognized in the majority of recovered HLA-B27 positive women. In chronically HCV-infected individuals, analysis of the corresponding viral sequence showed a strong association between sequence variations within this epitope and expression of HLA-B27, indicating allele-specific selection pressure at the population level. Functional analysis in 3 chronically HCV-infected patients showed that the emerging variant viral epitopes represent escape mutations. In conclusion, our results suggest a dominant role of HLA-B27 in mediating spontaneous viral clearance as well as viral evolution in HCV infection and mechanistically link both associations to a dominant novel CD8+ T cell epitope. These results support the central role of virus-specific CD8+ T cells and the genetically determined restriction of the virus-specific T cell repertoire in HCV infection. (HEPATOLOGY 2006;43:563-572.).
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em_102
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Re: HLA B27

Post by em_102 » Thu Feb 26, 2009 9:15 pm

I just recovered from my first case of iritis, which occurred in both eyes, when it spread into the other eye I was tested for HLA B27 and today I found out that I am HLA B27+. I'm not sure what this means? They said I would be prone to a form of arthritis and that I might have recurrent iritis. Are there any preventative treatments out there that I should be asking about or anything else I should know? I've already read many of the articles you suggested - I just want to be sure that I'm as aware as I can be.

Mike Bartolatz
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Re: HLA B27

Post by Mike Bartolatz » Fri Feb 27, 2009 7:59 am

the HLA B27 gene sometimes occurs with uveitis, iritis is anterior uveitis. this is a form of autoimmune uveitis. when combined with other 'markers' it can also cause ankylosing spondylitis, reactive arthritis, crohn's disease, ulcerative colitis and psoriatic arthritis in some individuals.
it is difficult to say if you will end up with any of these things.
when uveitis occurs, it starts in one eye, then when the eye is calmed down at a later date (impossible to tell how long) the other eye can get uveitis. this occurs repeatedly. it could be a week or so, several months or years between bouts of iritis. if it is recurrent with short intervals of a month or so between bouts, the next step on a stepladder approach to treatment would be to add an oral NSAID such as Celebrex, Dolobid, Naprosyn, feldene etc at prescription strength for a trial to see if this anti inflammatory can break the recurrent cycle. the goal is off all steroids without inflammation. once free of inflammation one continues to take the oral NSAID for TWO YEARS in order for the immune system to stop attacking your eyes. if this doesn't work (one should know within the first six months of therapy) then one would move on to the next step of DMARD drugs etc used in the same manner as described above.

I hope this helps,
Mike
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em_102
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Re: HLA B27

Post by em_102 » Fri Feb 27, 2009 10:23 am

That does! Thanks very much Mike! Your help is always appreciated!

Mike Bartolatz
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Re: HLA B27

Post by Mike Bartolatz » Fri Feb 27, 2009 11:20 am

ask any other questions you may have as well. I'll do my best to clear things up for you. I recall how difficult it was to understand allot of this about 10 years ago when I started doing research before there were any websites like this. That's one of the reasons I helped Kevin Build this site: so others wouldn't have to do allot of research without guidance .

Wish you quiet eyes and joints,
Mike
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doleriya
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Re: HLA B27

Post by doleriya » Thu Jul 16, 2009 4:37 am

What are the side effects of hepatitis vaccinations? I just got my hepatitis b shots in school today, please tell me what the side effects are! I got some side effects like less energy and sore body parts but what are other side effects.
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matrimonial
Last edited by doleriya on Sat Jul 18, 2009 2:09 am, edited 1 time in total.

Mike Bartolatz
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Re: HLA B27

Post by Mike Bartolatz » Thu Jul 16, 2009 9:02 am

http://www.medicinenet.com/hepatitis_b_ ... rticle.htm

above is a link to information on the HEP B vaccine which includes information on contraindications such as use with corticosteroids, cyclosporine etc often used in uveitis patients.

mike
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