Ankylosing Spondylitis, uveitis and pregnancy

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Mike Bartolatz
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Ankylosing Spondylitis, uveitis and pregnancy

Post by Mike Bartolatz » Mon Mar 03, 2008 5:39 pm

http://www.medicinenet.com/script/main/ ... ekey=16694

the IL23 gene also presents with Ankylosing spondyitis,
this article talks about women who have the HLA B27 gene and who get Uveitis and Ankylosing Spondylitis at a much higher frequency than the general population.
at up to 50%

mike
Mike Bartolatz
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Mike Bartolatz
Posts: 6595
Joined: Fri Feb 06, 2004 9:58 pm

post partum uveitis

Post by Mike Bartolatz » Thu Nov 06, 2008 11:15 am

Postpartum uveitis.Hyman BN.
A review of the literature supports the concept that serum levels of corticosteroids are elevated during pregnancy. Even a concurrent increase in cortisol-binding globulin (CBG) does not entirely neutralize the increased levels of cortisol. Thus, body tissues are exposed to more free cortisol than in the nonpregnant state. After delivery there is a rapid reduction of serum corticosteroids to the nonpregnant level. A granulomatous disease such as sarcoidosis may be suppressed by the high serum cortisol level. In the puerperium with a reduction of the serum cortisol, exacerbation of such a disease is likely. The case presented demonstrates this phenomenon.

PMID: 937950 [PubMed - indexed for MEDLINE]
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