IL23R, ERAP1, ANTXR2, IL1R2 in AS, Crohn's etc

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IL23R, ERAP1, ANTXR2, IL1R2 in AS, Crohn's etc

Post by Mike Bartolatz » Mon Dec 10, 2007 2:05 pm

The ARTS 1 gene is also known as the ERAP 1 gene: http://www.ncbi.nlm.nih.gov/sites/entre ... uids=51752
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HLA B27, ANTXR2, IL1R2, IL23R. ERAP1 (formerly ARTS1) and AS
by Mike Bartolatz on Tue Mar 16, 2010 12:22 pm

http://parsplanitisforum.yuku.com/topic/28

here are some newly discovered genetic links to Ankylosing spondlyitis and other autoimmune disease processes
recently the ANTXR2 and IL1R2 genes were discovered and the association with IL23R and ERAP1 (formerly ARTS!) genes were confirmed so in addition to HLA B27 the following genes are linked in anglo american and european persons:

HLA B27
ANTXR2
IL1R2
IL23R
ERAP1 (formerly ARTS1)

http://www.medscape.com/viewarticle/564590

"The diseases linked to these genes are ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis, and breast cancer.

The investigators suggest that IL23R, in particular, may be a common susceptibility factor for the major "seronegative" diseases. Earlier research has shown an association between IL23R and both inflammatory bowel disease (Crohn's disease) and psoriasis. " IL1RN is also implicated in ankylosing spondylitis

http://www.medscape.com/viewarticle/566849?src=mp
research article

Ankylosing Spondylitis, Crohn's disease, Systemic Lupus Erythematosis, Multiple Sclerosis
http://www.medscape.com/viewarticle/564590

expaned search on IL23 in Uvieitis shows increase in this cytokine in Behcet's patients,VKH patients etc
http://www.google.com/search?hl=en&q=IL ... h&aq=f&oq=

patent for anti IL23 in uveitis:
http://www.freshpatents.com/Use-of-il-2 ... 199460.php

research (with mice) and patent information
http://www.wipo.int/pctdb/en/wo.jsp?IA= ... SPLAY=DESC

simvastatin used to treat cholesterol levels inhibits IL17
http://www.jimmunol.org/cgi/content/abs ... 80/10/6988
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Post by Mike Bartolatz » Thu Nov 06, 2008 5:55 pm

http://ghr.nlm.nih.gov/gene=il23r

information on IL23R and Psoriais and Crohn's disease
Mike Bartolatz
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2 additional genes with three additional autoimmune diseases

Post by Mike Bartolatz » Thu Nov 06, 2008 6:01 pm

http://www.medpagetoday.com/Rheumatolog ... ology/7055

confirmed link to ankylosing spondylitis with the ARTS 1 gene

two other genes identified for autoimmune thyroid disease( TSHR and FCRL3 ) in this article as well as links to Multiple Sclerosis
http://ard.bmj.com/cgi/content/abstract/67/10/1451 specific subset for ankylosing spondylitis
Mike Bartolatz
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Re: 2 genes, 4 major disorders

Post by Mike Bartolatz » Sun Nov 30, 2008 7:06 pm

1: Curr Opin Rheumatol. 2008 Jul;20(4):384-91. Links
The contribution of genes outside the major histocompatibility complex to susceptibility to ankylosing spondylitis.Brionez TF, Reveille JD.
Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.

PURPOSE OF REVIEW: Recent data have presented several new nonmajor histocompatibility complex genes in predisposition to ankylosing spondylitis, which will be summarized here. RECENT FINDINGS: A retrospective meta-analysis of three previous whole genome linkage scans confirmed a strong linkage at chromosome 16q and moderate linkage at sites on chromosomes 3, 10, and 19q, and a meta-analysis of studies of the interleukin-1 (IL-1) region genes in ankylosing spondylitis suggested the susceptibility to be conferred by the IL-1A gene. More recently, the use of genotyping chips, derived from the International Hapmap resource, which provides an extensive genomic coverage of large disease cohorts, have made it possible to conduct successful genome-wide association studies. One such study has led to the identification and validation of two new genes, IL23R and ARTS1, in ankylosing spondylitis pathogenesis. SUMMARY: A tremendous amount of progress has been made with respect to understanding the genetic basis of ankylosing spondylitis. The recent identification of two new genes, ARTS1 and IL23R, and confirmation of IL-1A association further substantiate that ankylosing spondylitis is determined to a large extent by genes outside the major histocompatibility complex.

PMID: 18525349 [PubMed - indexed for MEDLINE]
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Re: 2 genes, 4 major disorders

Post by Mike Bartolatz » Tue Dec 02, 2008 1:30 pm

http://www.ncbi.nlm.nih.gov/pubmed/1844 ... t=Abstract

a series of abstracts on research into various autoimmune disease processes to include Ankylosing Spondylitis, Rheumatoid arthritis, Systemic Lupus Erythematosus, Sjogren's syndrome, Crohn's disease and various cytokines, chemokines, gentics and disease modification with DMARD and Biological Response modifying drugs
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Re: 2 genes, 4 major disorders

Post by Mike Bartolatz » Tue Dec 02, 2008 2:00 pm

http://www.google.com/search?hl=en&sa=X ... 17&spell=1

Cyclosporin A inhibits IL17 production
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Re: 2 genes, 4 major disorders

Post by Mike Bartolatz » Tue Dec 02, 2008 4:02 pm

IL2 expression can influence TH 17 . Zenepax ( Daclizumab ) effects IL 2 in some forms of Uveitis

http://www.google.com/search?hl=en&q=IL ... tnG=Search
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Re: 2 genes, 4 major disorders

Post by Mike Bartolatz » Tue Dec 02, 2008 5:17 pm

Mike Bartolatz
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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Tue Dec 02, 2008 5:32 pm

Specific location on the IL1RN gene (haplotype) for ankylosing spondylitis

http://lib.bioinfo.pl/pmid:12847695
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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Wed Dec 10, 2008 4:05 pm

http://www.medicalnewstoday.com/articles/96802.php

Useteminubab application to FDA for approval to treat Psoriatic Arthritis
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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Thu Dec 11, 2008 12:00 am

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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Fri Jan 02, 2009 2:40 pm

IL21 in TH17 cell production
http://www.pubmedcentral.nih.gov/articl ... id=2323680

other cytokines such as IL6, IL17, IL23 are also implicated in TH 17 production
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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Fri Jan 02, 2009 2:45 pm

Mike Bartolatz
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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Thu Jan 22, 2009 12:00 pm

http://www.biopharma.com/Samples/235.html

usetekinumab, biolotical antigonist against IL12 and TH17, application to FDA and european Drug authorities for use,
NOT YET APPROVED for use.

mike
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Mike Bartolatz
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Re: 3 genes, 4 major disorders

Post by Mike Bartolatz » Thu Jan 22, 2009 12:07 pm

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